Peptide Therapy

 

What is Peptide Therapy?

Peptides are the building blocks of proteins and are composed of amino acids that work to regulate a variety of biological functions and processes. These naturally occurring peptides act as signaling molecules within the body and instruct other cells and molecules on what functions to perform.
There are over 7,000 known peptides within the human body and though some may be similar each is responsible for facilitating a different response and action within the body. Some common functions of peptides include providing pain relief, aiding in soft tissue repair, accelerating healing processes, promoting weight loss and lean muscle gain, reversing symptoms of sexual dysfunction, and improving hormone production and cognitive function. The unique property of peptides can be harnessed and used to treat specific conditions; this treatment process is known as peptide therapy.

Peptide Therapies

AOD9604
DESCRIPTION: AOD9604 is a GH fragment which comprised the last 16 amino acids of the larger growth hormone molecule. Although originally studied for fat loss, further studies have transitioned it’s application for regenerative medicine. In combination with hyaluronic acid (HA), it is now being used to help regenerate hyaline cartilage and is showing strong efficacy in the treatment of osteoarthritis. The combination acts to enhance the differentiation of adipose mesenchymal stem cells into bone, promote proteoglycan and collagen production in chondrocytes, and promote differentiation of myoblasts into C2C12 cells; all of which are essential for bone, cartilage, and muscle repair. These studies indicate that it has stronger therapeutic benefits compared to Bone Marrow Aspirate Concentrate (BMAC) and Platelet Rich Plasma (PRP) therapy, which have also been emerging as candidates for osteoarthritis medications. AOD9604 + HA has proceeded to human WOMAC trials which allow the combination to be investigated for on an osteoarthritis index which considers pain, stiffness, and functionality on a variety of scores
BPC 157
DESCRIPTION: Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. Additionally, BPC 157 has shown to protect organs and aids in the prevention of gastric ulcers. BPC-157 acts systemically in the digestive tract to combat leaky gut, IBS, gastrointestinal cramps, and Crohn’s disease. This peptide has been known to exhibit analgesic characteristics as well. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help to aid skin burns at a faster rate by increasing blood flow to damaged tissues
CJC-1295
DESCRIPTION: CJC 1295 stimulates growth hormone release via binding to the pituitary. This peptide directly mimics the endogenous Growth Hormone Releasing Hormone (GHRH) typically secreted by the hypothalamus. As a result of better stimulation and release you see many clinical results including fat loss, increases lean muscle mass, better lipid profiles, better deep wave sleep and increased repair and recovery. Use in combination with Ipamorelin, the CJC is one of the most widely prescribed products
Ipamorelin
DESCRIPTION: Ipamorelin is a peptide used to help growth hormone production. Ipamorelin is composed of five amino acids that stimulate the pituitary gland to produce more growth hormone naturally. This results in increased plasma GH levels, which would affect many biological processes, such as in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue, and immune cells. Unlike other GH releasing peptides, Ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone.
Sermorelin
DESCRIPTION: Sermorelin is a peptide analog of Growth Hormone Releasing Hormone used as a diagnostic agent to assess growth hormone secretion to diagnose growth hormone deficiency. It is a 29-amino acid polypeptide representing the 1–29 fragment from endogenous human GHRH, thought to be the shortest fully functional fragment of GHRH.
Thymosin Beta-4 (TB_500)
DESCRIPTION: Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of Thymosin, Thymosin Beta 4, is a member of a highly conserved family of actin monomer sequestering proteins. In addition to its role as a major actin-sequestering molecule, Thymosin Beta 4 plays a role in tissue repair. Tβ4 has been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues. The gene for Tβ4 has also been found to be one of the first to be upregulated after injuries. Thymosin Beta 4 is currently being trialed as a potential therapy for HIV, AIDS, and Influenza. Thymosin Beta 4 is most often prescribed for acute injury, surgical repair and for senior athletes. It has most recently been shown to help regrow hair in addition to PRP
Epithalon
DESCRIPTION: Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in humans. The pineal peptide preparation is secreted in the epithalamium-epiphyseal region of the brain. Its more prominent tasks are: to regulate metabolism in the epiphysis, increase the sensitivity of hypothalamus to its natural hormonal influences, normalize the function of the anterior pituitary, regulate the levels of gonadotropins and melatonin in the body. Epithalamin increases a person’s resistance to emotional stress and also acts as an antioxidant. It is a bio-regulator for the endocrine system, especially for the pineal gland, and has been shown to lengthen telomeres in human cells. The mechanisms in Epitalon are a lot more complex than just activating telomerase. It reduces lipid oxidation and ROS, along with normalizing T cell function. It seems to normalize cholesterol and uric acid, along with prolactin levels. It has shown promise in restoring pancreatic hormone function. Additionally, it restored and normalized melatonin levels in older patients who have lost some pineal function due to aging.
GHK-Cu (Copper)
DESCRIPTION: GHK-Cu is a naturally occurring copper complex that was first identified in human plasma, but has hence been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, but not limited to, promoting activation of wound healing, attracting immune cells, antioxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. First, it seems to act as a potent protector of tissue and anti-inflammatory agent that controls the oxidative damage that occurs post-tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction. Clinically, it is mostly used to decrease fine lines and wrinkles and to improve hair regrowth.
Thymosin Alpha-1
DESCRIPTION: It is an FDA approved medication under the trade name zadaxin after it received orphan drug approval status. It is widely used and studied in multiple types of cancer and viral illnesses. Some physicians are using thymosin for chronic fatigue and Lyme disease as well as autoimmune function as well. TA 1 is thought to modulate the immune system by augmenting T-cell function. TA1 may affect thymocytes by stimulating their differentiation or by converting them to active T cells. TA1 is rapidly absorbed, achieving peak serum concentrations within two hours.
 

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